論文発表

  1. •遺伝病、遺伝子変異によるタンパク質立体構造への影響の解析

  2. 遺伝子の変異、臨床と立体構造との関連の解析

  3. Dystonia and Parkinsonism in COA7-related disorders: expanding the phenotypic spectrum.

  4. J Neurol. 2024 Jan;271(1):419-430. doi: 10.1007/s00415-023-11998-3. PMID: 37750949.


  1. Difference in Clinical Phenotype, Mutation Position, and Structural Change of RNF213 Rare Variants Between Pediatric and Adult Japanese Patients with Moyamoya Disease.

  2. Transl Stroke Res. 2023. Epub ahead of print. PMID: 37768541.


  1. Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.

  2. Oncol Rep. 2022 :32. doi: 10.3892/or.2021.8243. PMID: 34935060.


  1. Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR

  2. Variants.

  3. Diabetes. 2021 70(8):1874-1884. PMID: 34074726


  1. Clinical usefulness of multigene screening with phenotype-driven bioinformatics analysis for the diagnosis of patients with monogenic diabetes or severe insulin resistance.

  2. Diabetes Res Clin Pract. 2020 Nov;169:108461. PMID: 32971154


  1. •酵素とコレステロールとの相互作用の解析

  2. Esterification of side-chain oxysterols by lysosomal phospholipase A2.

  3. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Oct;1865(10):158787   PMID: 32777483


  1. •薬理効果を持つ植物由来化合物とヒト受容体との相互作用の解析

  2. Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta.

  3. Molecules. 2017 Dec 29;23(1):74.   PMID: 29286333


  1. •相分離におけるRNA結合タンパク質の凝集化及び新規低分子化合物との相互作用の解析

  2. Biotin-Lys-His Blocks Aggregation of RNA-binding Protein TLS, a Cause of Amyotrophic Lateral Sclerosis.

  3. Biomedical Sciences. 2017 July;3(4): 67-77


  1. •酵素の立体構造モデリングと基質との相互作用の解析

  2. Structural modeling and mutagenesis of endo-b-N-acetylglucosaminidase from Ogataea minuta identifies the importance of Trp295 for hydrolytic activity. J Biosci Bioeng. 2018 Feb;125(2):168-174. PMID: 28903882


  1. •ファミリータンパク質のモデリングと表面電荷の比較

  2. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors.J Biol Chem. 2009 Dec 18;284(51):35273-7. PMID: 19846560


  1. •酵素と新規阻害剤との相互作用の解析



特許申請

  1. •よりコンパクトで薬理効果の高いペプチド性アゴニストの設計

  2. •特定の有効成分を高産生するメカニズムの解明

  3. •変異導入による高活性型酵素の作製

  4. •薬理活性を有する新規低分子


解析の実績（論文発表、特許申請）　公開されている一部をご紹介しています